Supplement of iron abrogates SARS-CoV-2 pseudovirus infection in a 3D model of vascularized organoids

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause severe outbreak of coronavirus disease 2019 (COVID-19). Even though vaccination, the spread of SARS-CoV-2 is still continue. It is urgent to have a model that can efficiently evaluate potential therapeutic agents to counteract SARS-CoV-2 infection. Iron is an essential molecule for maintaining homeostasis. Supplement of iron significantly to affect virus infection. But the detailed mechanisms of iron on regulating SARS-CoV-2 infection are still unveiled. The three-dimensional (3D) model is a promising system for drug screening and disease progression analysis. Organoid is a typical 3D culture system that recapitulates genetic characteristics and phenotypic features of organs within body. Vasculature is prevalent for all various organs or tumors in the body which transport nutrients, oxygen and metabolites to maintain cellular homeostasis. Thus, we have established a 3D model of vascularized organoid to evaluate the effects of iron on infectivity of SARS-CoV-2 pseudovirus to provide the novel therapeutic strategy in coping SARS-CoV-2 infection. © 2022 IEEE.

The reshoring decision under uncertainty in the post-COVID-19 era

Purpose: Using insights from the supply chain resilience perspective and the international business literature, this study aims to investigate the determinants of firms’ decisions to reshore manufacturing under the high levels of uncertainty brought about by the ongoing US–China trade war and COVID-19 pandemic. Design/methodology/approach: The proposed conceptual framework is tested using survey data collected from 702 Taiwanese firms with manufacturing in China. The firms were drawn from a database compiled by Taiwan’s Ministry of Economic Affairs. Findings: The results show that two supply chain factors (tariffs and supply chain completeness) and two non-location-bound factors (labor cost and material cost) are critical determinants of the decision to reshore under uncertainty. Originality/value: This research elucidates and empirically validates several factors that influence the reshoring decision in uncertain environments. The findings provide valuable theoretical, practical and strategic insights into how firms should manage their value chains in the post-COVID-19 era. © 2021, Emerald Publishing Limited.